Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes / 生理学报
Acta Physiologica Sinica
;
(6): 513-522, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827035
ABSTRACT
Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Luteinizing Hormone
/
Natriuretic Peptide, C-Type
/
Cumulus Cells
/
Genetics
/
Meiosis
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2020
Type:
Article
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