Source, metabolism and function of dopamine in digestive tract / 生理学报
Acta Physiologica Sinica
;
(6): 336-346, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827054
ABSTRACT
Dopamine (DA), as a catecholamine neurotransmitter widely distributed in the central nervous system and the peripheral tissues, has attracted a lot of attention. Especially in recent years, DA has been found to regulate the function of the immune system, and the involvement of DA in the intestinal mucosal inflammation-related diseases has become a hot research topic. The digestive tract is an important source of peripheral DA, and DA is not only produced in the enteric nervous system and gastrointestinal epithelium, but also produced by intestinal microorganisms. In addition to the synthetases of DA, the DA contents in body tissues are also affected by the two kinds of metabolic enzymes, monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). This article reviewed the sources, metabolism, and functions of DA in digestive tract, especially focusing on the distribution and function of MAO and COMT, the enzymes degrading DA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dopamine
/
Catechol O-Methyltransferase
/
Gastrointestinal Tract
/
Catechol O-Methyltransferase Inhibitors
/
Monoamine Oxidase
/
Monoamine Oxidase Inhibitors
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS