Usefulness of Diffusion Tensor Tractography in Pediatric Epilepsy Surgery
Yonsei Medical Journal
;
: 21-27, 2013.
Article
in English
| WPRIM
| ID: wpr-82711
ABSTRACT
PURPOSE:
This study was conducted to assess the clinical relevance of diffusion tensor tractography (DTT) in pre- and post-operative evaluations of childhood epilepsy surgery. MATERIALS ANDMETHODS:
Seventy-two patients who received epilepsy surgery between March 2004 and July 2008 were retrospectively analyzed (M F=40 32, ages of 3 months to 24 years, mean age=8.9 years). DTT was performed using a 3.0 T scanner and single-shot spin-echo echo-planar imaging with 32-different diffusion gradient directions. We reviewed the data focusing on the type of surgery, final pathological diagnosis, and how the DTT data were clinically used.RESULTS:
The most common form of childhood epilepsy surgery was complete resection of an epileptogenic lesion (n=52, 72.2%). The reported etiologies included cortical dysplasia (n=32, 44.4%), hippocampal sclerosis (n=9, 12.5%), brain tumors (n=7, 9.7%), and non-pathologic lesions (n=4, 5.6%) in the final diagnoses. Twenty-one dysplastic cortexes and four brain tumors involved an approximal relationship with the corticospinal tract (n=18), optic radiation (n=2), and arcuate fasciculus (n=5). Additionally, although DTT demonstrated white matter tracts clearly, DTT in the hippocampal sclerosis did not provide any additional information. In cases of callosotomy (n=18, 25%), post-operative DTT was utilized for the evaluation of complete resection in all patients. DTT information was not used in functional hemispherectomy (n=2, 2.8%).CONCLUSION:
Preoperatively, DTT was a useful technique in cases of cortical dysplasia and brain tumors, and in cases with callosotomy, postoperatively. DTT should be included among the routine procedures performed in management of epilepsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sclerosis
/
Seizures
/
Brain Neoplasms
/
Retrospective Studies
/
Treatment Outcome
/
Epilepsy
/
Diffusion Tensor Imaging
/
Hippocampus
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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