Roles of PET/CT in Predicting the Prognosis of Diffuse Large B Cell Lymphoma Patients Treated with Chimeric Antigen Receptor T Cell Therapy / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1189-1196, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827141
ABSTRACT
OBJECTIVE@#To investigate the prognosis prediction value of PET/CT in DLBCL patients treated with CAR-T therapy.@*METHODS@#The effects of PET/CT were retrospectively explored on 13 R/R DLBCL patients who were treated with CAR-T therapy. Parameters reflecting tumor metabolic burden, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured before and after CAR-T treatment.@*RESULTS@#Patients with larger baseline MTV or longer sum of longest diameters showed shorter overall survival (OS) time than those with low tumor burden. Patients achieved complete remission (CR), partial remission (PR) and minor remission (MR) determined by response evaluation criteria in lymphoma (RECIL) in 12 weeks showed progression-free survival and OS time superior to those of patients with no remission. In addition, it was found that 2 patients with residual masses classified as PR by contrast-enhanced CT of patients were evaluated as complete metabolic response by PET/CT imaging.@*CONCLUSION@#PET/CT shows a great value in the evaluation of prognosis and response in CAR-T-treated R/R DLBCL patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Retrospective Studies
/
Lymphoma, Large B-Cell, Diffuse
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Cell- and Tissue-Based Therapy
/
Positron Emission Tomography Computed Tomography
/
Receptors, Chimeric Antigen
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2020
Type:
Article
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