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Relationship of Expression of Circ_cgga162 with the Prognosis of Patients with Mantle Cell Lymphoma / 中国实验血液学杂志
Article in Chinese | WPRIM | ID: wpr-827192
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of Circ_cgga162 in serum of mantle cell lymphoma (MCL) patients and analyze its potential as a prognostic biomarker.@*METHODS@#The expression of Circ_cgga162 in 86 cases of mantle cell lymphoma and 50 cases of lymph node reactive hyperplasia (RH) were detected by real-time quantitative polymerase chain reaction (qRT-PCR). The relationship between the expression of Circ_cgga162 and clinicopathological features was analyzed by univariate analysis. The relationship of Circ_cgga162 expression with progression-free survival time and overall survival time was analyzed by Kaplan-Meier. The relationship between expression of Circ_cgga162 and prognosis of patients was analyzed by univariate and multivariate analysis.@*RESULTS@#The expression level of Circ_cgga162 in MCL patients was significantly higher than that in control (RH) group (P<0.01). The expression of Circ_cgga162 not correlated with age, gender, B symptoms and LDH (all P>0.05), but correlated with the expression of MCL International Prognostic Index (IPI), Ann Arbor stage, bone marrow infiltration and Ki67 (all P<0.05). In addition, Kaplan-Meier analysis showed that the progression-free survival time and overall survival time of the MCL patients with high expression of Circ_cgga162 were significantly shorter than those of the MCL patients with low expression (P<0.01). Univariate analysis showed that Ann Arbor stage, Circ_cgga162 expression, MIPI, bone marrow infiltration and Ki67 were the prognostic factors for MCL patients (all P<0.05). Multivariate Cox regression analysis showed that Ann Arbor stage, Circ_cgga162 expression and MIPI were independent factors affecting the prognosis of MCL patients (all P<0.05).@*CONCLUSION@#Circ_cgga162 is highly expressed in serum of patients MCL, which relates with the prognosis of MCL patients. Circ_cgga162 can be used as a potential prognostic marker and therapeutic target for MCL patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Humans / Multivariate Analysis / Lymphoma, Mantle-Cell / Kaplan-Meier Estimate / RNA, Circular / Genetics Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Humans / Multivariate Analysis / Lymphoma, Mantle-Cell / Kaplan-Meier Estimate / RNA, Circular / Genetics Language: Chinese Journal: Journal of Experimental Hematology Year: 2020 Type: Article