Chondrocyte cocultures with stromal vascular fraction of adipose tissue promote cartilage regeneration in vivo / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 240-244, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827552
ABSTRACT
OBJECTIVE@#This study aimed to compare the cartilage regeneration of the stromal vascular fraction (SVF) cells and adipose-derived mesenchymal stem cells (ASCs) cocultured with chondrocytes seeded on the scaffolds.@*METHODS@#The cellular morphologies and proliferation capabilities on the scaffolds were evaluated. The scaffolds with the cocul-ture of ASCs/SVF and chondrocytes were implanted into the full thickness cartilage defective rabbit joints for 10 weeks.@*RESULTS@#The cells seeded into the scaffolds showed good adhesion and proliferation. Implantation with SVF and chondrocytes revealed desirable in vitro healing outcomes.@*CONCLUSIONS@#The SVF cells were better than ASCs in terms of the formation of cartilage matrix in a coimplantation model. Without in vitro expansion, the SVF cells are good cell sources for cartilage repair.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Cartilage
/
Adipose Tissue
/
Coculture Techniques
/
Chondrocytes
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2020
Type:
Article
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