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Chondrocyte cocultures with stromal vascular fraction of adipose tissue promote cartilage regeneration in vivo / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 240-244, 2020.
Article in Chinese | WPRIM | ID: wpr-827552
ABSTRACT
OBJECTIVE@#This study aimed to compare the cartilage regeneration of the stromal vascular fraction (SVF) cells and adipose-derived mesenchymal stem cells (ASCs) cocultured with chondrocytes seeded on the scaffolds.@*METHODS@#The cellular morphologies and proliferation capabilities on the scaffolds were evaluated. The scaffolds with the cocul-ture of ASCs/SVF and chondrocytes were implanted into the full thickness cartilage defective rabbit joints for 10 weeks.@*RESULTS@#The cells seeded into the scaffolds showed good adhesion and proliferation. Implantation with SVF and chondrocytes revealed desirable in vitro healing outcomes.@*CONCLUSIONS@#The SVF cells were better than ASCs in terms of the formation of cartilage matrix in a coimplantation model. Without in vitro expansion, the SVF cells are good cell sources for cartilage repair.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Regeneration / Cartilage / Adipose Tissue / Coculture Techniques / Chondrocytes Limits: Animals Language: Chinese Journal: West China Journal of Stomatology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Regeneration / Cartilage / Adipose Tissue / Coculture Techniques / Chondrocytes Limits: Animals Language: Chinese Journal: West China Journal of Stomatology Year: 2020 Type: Article