Application of in situ amniocyte culture for prenatal diagnosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 1117-1119, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-827731
ABSTRACT
OBJECTIVE@#To explore the value of in situ amniocyte culture for prenatal diagnosis.@*METHODS@#2716 amniotic fluid samples were cultured in situ on slides. After the culture, the slides were stained, photographed and analyzed.@*RESULTS@#All samples were successfully analyzed, with the success rates for primary culture and subculture being 98.42% and 1.58%, respectively. 224 samples (8.25%) were detected with chromosomal aberrations, which included 125 cases with trisomy 21, 31 with trisomy 18, 3 with trisomy 13, 4 with 45,X, 17 with 47,XXY, 5 with 47,XYY, 1 with 48,XXY,+18, 1 with 48,XXYY, 26 with structural chromosomal aberrations, and 11 with mosaicisms for aneuploidies.@*CONCLUSION@#In situ amniocyte culture is stable and has a high success rate, and is capable of identifying true and false mosaicisms, which can improve the accuracy of prenatal diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2020
Type:
Article
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