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Epidemiological analysis of liver injury related to bone diseases / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3974-3980, 2020.
Article in Chinese | WPRIM | ID: wpr-828359
ABSTRACT
A total of 1 392 reports on liver injury associated adverse drug reaction(LI-ADR) related to bone diseases were retrospectively analyzed based on national ADR monitoring system [18.75% of the patients used traditional Chinese medicine(TCM) alone and 68.68% used Western medicine alone]. This kind of cases accounted for 2.5% of all drug-related liver injury adverse reactions, ranking top ten of all drug categories. The number of reported cases and the proportion of serious cases showed an increasing trend from 2012 to 2016. The average age of the patients was(54.2±15.8) years old, and there was little difference in overall gender(male-female 1.04∶1). However, the number of female patients with rheumatoid arthritis was significantly higher than that of male patients(male-female 1∶2.6), while the number of male patients with gout was significantly higher than that of female patients(male-female 7.16∶1). The overall prognosis was good, with the recovery and improvement rate of 85.27%. The time from medication to liver injury varied due to different medicines. The median time to liver injury was 27 days in TCM alone group, later than 11 days in Western me-dicine alone group(P<0.05). Drugs for bone diseases have been one of the important categories for clinical drug-induced liver injury, and the number of reported cases on liver injury caused by drugs for bone diseases is increasing, so we should pay close attention to the safe and rational use of them. The LI-ADRs of male and female were different due to their different diseases, and the latency of adverse reactions in TCM group was generally longer than that in Western medicine group. In clinical medication, liver function should be monitored according to different diseases and characteristics of drugs to prevent the risk of liver injury.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Diseases / Drugs, Chinese Herbal / Retrospective Studies / Drug-Related Side Effects and Adverse Reactions / Medicine, Chinese Traditional Type of study: Diagnostic study / Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Diseases / Drugs, Chinese Herbal / Retrospective Studies / Drug-Related Side Effects and Adverse Reactions / Medicine, Chinese Traditional Type of study: Diagnostic study / Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2020 Type: Article