Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
The Korean Journal of Internal Medicine
;
: 261-268, 2017.
Article
in English
| WPRIM
| ID: wpr-82847
ABSTRACT
BACKGROUND/AIMS:
Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood monocyte cell (PBMC) in cirrhotic patients.METHODS:
A total of nine decompensated cirrhotic patients were randomized into three groups group 1 (n = 3) was control group, group 2 (n = 3) received granulocyte-colony stimulating factor (G-CSF) mobilization for 3 days, and group 3 (n = 3) received G-CSF mobilized PBMCs by leukapheresis and PBMC transplantation through ultrasound-guided percutaneous portal vein puncture. Liver function and clinical features were evaluated.RESULTS:
At baseline, the Child-Turcotte-Pugh and the model for end-stage liver disease scores were comparable in study groups. Compared with group 1, there was a tendency to improve liver function in group 3 at 6 months after treatment. Treatment was tolerable and no complications were encountered related to the G-CSF mobilization or percutaneous portal administration of PBMCs. Imaging studies showed patent portal veins at the end of the study period.CONCLUSIONS:
Autologous PBMC transplantation through ultrasound-guided percutaneous portal vein puncture could be considered as a safe alternative treatment for decompensated cirrhotic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Portal Vein
/
Stem Cells
/
Tissue Donors
/
Fibrosis
/
Leukocytes, Mononuclear
/
Monocytes
/
Punctures
/
Granulocyte Colony-Stimulating Factor
/
Leukapheresis
/
Liver Transplantation
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2017
Type:
Article
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