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Efficacy and safety of letrozole in treatment of male children with disorders of sex development / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 297-301, 2020.
Article in Chinese | WPRIM | ID: wpr-828501
ABSTRACT
OBJECTIVE@#To investigate the efficacy and safety of aromatase inhibitor letrozole in treatment of male children with disorders of sex development (DSD).@*METHODS@#Clinical data of 12 male DSD children with a mean age of 14.6±2.5 years admitted to Peking Union Medical College Hospital from January 2014 to January 2016 were retrospectively analyzed. The patients were treated with letrozole (1.25-2.5 mg, once a day) for 3 months or longer, and followed up for 0.5-2.5 years. Clinical manifestation and laboratory test findings were documented, and the efficacy and safety were evaluated.@*RESULTS@#After half-year treatment, the blood luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels of patients increased (all < 0.05), and estrogen levels decreased from baseline ( < 0.05). After 1 year of treatment, the blood testosterone level was significantly higher ( < 0.05); the LH and FSH levels tended to increase and the estrogen level tended to decrease, but there was no significant statistical difference ( >0.05). Semen was routinely detected in 8 patients, and sperms were detected in semen of 3 patients with hypospadias. There were no significant changes in biochemical results after treatment, and no significant adverse event was observed during the treatment.@*CONCLUSIONS@#Letrozole can effectively increase testosterone levels in patients with disorders of sex development and promote spermatogenesis, it has no significant adverse effects in short-term administration.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Disorders of Sex Development / Testosterone / Luteinizing Hormone / Retrospective Studies / Therapeutic Uses / Drug Therapy / Letrozole / Follicle Stimulating Hormone Type of study: Observational study Limits: Adolescent / Child / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Disorders of Sex Development / Testosterone / Luteinizing Hormone / Retrospective Studies / Therapeutic Uses / Drug Therapy / Letrozole / Follicle Stimulating Hormone Type of study: Observational study Limits: Adolescent / Child / Humans / Male Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2020 Type: Article