Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer; Significance of 5-FU Concentration Monitoring / 대한암학회지
Journal of the Korean Cancer Association
;
: 516-523, 2000.
Article
in Korean
| WPRIM
| ID: wpr-82864
ABSTRACT
PURPOSE:
To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adendegrees Carcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome. MATERIALS ANDMETHODS:
Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chro matography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied.RESULTS:
Response rate of FP chemotherapy was 46% (95% C.I. 30~62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patient to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05).CONCLUSION:
We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Stomach Neoplasms
/
Pharmacokinetics
/
Cisplatin
/
Treatment Outcome
/
Area Under Curve
/
Drug Therapy
/
Fluorouracil
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
2000
Type:
Article
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