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Role of NLRP1 and NLRP3 inflammasome signaling pathways in the immune mechanism of inflammatory bowel disease in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 854-859, 2020.
Article in Chinese | WPRIM | ID: wpr-828655
ABSTRACT
OBJECTIVE@#To study the role of nucleotide-binding oligomerization domain-like receptor proteins 1 and 3 (NLRP1 and NLRP3) inflammasome signaling pathways in the immune mechanism of inflammatory bowel disease (IBD) in children.@*METHODS@#A total of 126 children with IBD were enrolled as the study group, including 32 children with Crohn's disease (CD) and 94 children with ulcerative colitis (UC). A total of 120 children who underwent colectomy were enrolled as the control group. The mRNA expression of NLRP1, NLRP3, Caspase-1, and interleukin-1β (IL-1β) was compared between groups.@*RESULTS@#The study group had significantly higher mRNA expression of NLRP1, NLRP3, Caspase-1, and IL-1β than the control group, and their mRNA expression levels tended to increase with the severity of CD or UC (P<0.05). In the children with UC or CD, the mRNA expression levels of NLRP1, NLRP3, Caspase-1, and IL-1β were positively correlated with serum IgM and IgG levels (P<0.05), and the mRNA expression levels of NLRP1 and NLRP3 were positively correlated with those of Caspase-1 and IL-1β (P<0.05).@*CONCLUSIONS@#The NLRP1 and NLRP3 inflammasome signaling pathways may regulate the immune mechanism of IBD in children by upregulating the expression of Caspase-1 and IL-1β.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Inflammatory Bowel Diseases / Signal Transduction / Adaptor Proteins, Signal Transducing / Apoptosis Regulatory Proteins / Interleukin-1beta / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Inflammatory Bowel Diseases / Signal Transduction / Adaptor Proteins, Signal Transducing / Apoptosis Regulatory Proteins / Interleukin-1beta / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article