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CD20 is not a poor prognostic factor for childhood B-lineage acute lymphoblastic leukemia with high white blood cell count / 中国当代儿科杂志
Article in Chinese | WPRIM | ID: wpr-828676
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To study the significance of CD20 combined with white blood cell (WBC) count at diagnosis in the prognosis assessment in children with B-lineage acute lymphoblastic leukemia (ALL).@*METHODS@#A retrospective analysis was performed on the medical data of 821 B-ALL children who were treated with CCLG-ALL2008 regimen from April 2008 to April 2015. Their survival status was followed up.@*RESULTS@#Among the 821 children, 547 (66.6%) were negative, while 274 (33.4%) were positive for CD20 expression. Among 694 children with WBC50×10/L (higher WBC count), the 5-year EFS rates was 64.3%±7.7% and 53.7%±5.5% for CD20 positive and negative patients respectively (P=0.135); the 5-year OS rate was 81.4%±6.4% and 58.6%±5.6% for CD20 positive and negative patients respectively (P=0.022); CD20 positive expression was an independent protective factor for OS (HR=0.367, P=0.016).@*CONCLUSIONS@#In children with B-ALL who are treated with CCLG-ALL2008 regimen, those with CD20 positive expression in lower WBC count at diagnosis have a poor prognosis; however, those with CD20 positive expression in higher WBC count at diagnosis have a better long-time survival.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Humans / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Combined Chemotherapy Protocols / Child / Retrospective Studies / Disease-Free Survival / Antigens, CD20 / Diagnosis / Leukocyte Count Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Humans / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Combined Chemotherapy Protocols / Child / Retrospective Studies / Disease-Free Survival / Antigens, CD20 / Diagnosis / Leukocyte Count Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article