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Sedative effect of intranasal midazolam in neonates undergoing magnetic resonance imaging: a prospective single-blind randomized controlled study / 中国当代儿科杂志
Article in Chinese | WPRIM | ID: wpr-828725
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To compare intranasal midazolam and intramuscular phenobarbital sodium for their sedative effect in neonates undergoing magnetic resonance imaging (MRI).@*METHODS@#A total of 70 neonates who underwent cranial MRI from September 2017 to March 2019 were randomized into an observation group and a control group, with 35 cases in each group. The observation group received intranasal drops of midazolam (0.3 mg/kg), and the control group received intramuscular injection of phenobarbital sodium (10 mg/kg). The sedation status of the neonates was evaluated using the Ramsay Sedation Scale. Meanwhile, the two groups were compared for the success rate of MRI procedure and incidence of adverse reactions.@*RESULTS@#In the observation group, the sedation score was the highest at 20 minutes post administration, then was gradually decreasing, and decreased to the lowest level at 70 minutes post administration. In the control group, the sedation score was the lowest at 10 minutes post administration, then was gradually increasing, and increased to the highest level at 40 minutes and 50 minutes post administration, followed by a gradual decrease. Comparison of the sedation score at each time period suggested that the sedation score was significantly higher in the observation group than in the control group within 40 minutes post administration (P0.05). The success rate of MRI procedure was significantly higher in the observation group than in the control group (89% vs 69%, P0.05).@*CONCLUSIONS@#Intranasal midazolam is superior to intramuscular phenobarbital sodium in the sedative effect in neonates undergoing MRI, with the benefits of being fast, convenient, safe, and effective.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Midazolam / Humans / Infant, Newborn / Magnetic Resonance Spectroscopy / Single-Blind Method / Prospective Studies / Hypnotics and Sedatives Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Midazolam / Humans / Infant, Newborn / Magnetic Resonance Spectroscopy / Single-Blind Method / Prospective Studies / Hypnotics and Sedatives Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article