Inhibitory and Eliminating Effects of Yeast-extracted Melanoston on Pigmentation and Preexisting Pigmentation, Respectively / 대한피부과학회지
Korean Journal of Dermatology
;
: 391-398, 2006.
Article
in Korean
| WPRIM
| ID: wpr-8294
ABSTRACT
BACKGROUND:
Melanoston is a new melanogenesis inhibitor isolated from yeast. However, little is known about the mechanism of this agent in melanogenesis and also its clinical effectiveness on hyperpigmented lesions.OBJECTIVE:
The purpose of this study was to examine the inhibitory effect of melanoston on in vivo activity of tyrosinase.METHODS:
We assessed tyrosinase activity, which participates in the synthesis of melanin pigment and resides in melanocytes of guinea pig's epidermis, using immunohistochemical methods after application of 0.1% and 0.01% melanoston on the skin of guinea pigs. We also conducted an 8-week clinical trial on 30 women volunteers to determine the clinical efficacy and safety of melanoston. Participants were instructed to apply melanoston and vehicle on 7 small areas of skin on both forearms for 8 weeks, before and after UVB exposure, and they were examined daily for the first week, then weekly thereafter.RESULTS:
The lowest level of tyrosinase activity was observed at the 3rd week after application of 0.1% and 0.01% melanoston on the skin of guinea pigs, and melanoston had a relatively strong inhibitory effect on tyrosinase, as compared with vehicle and arbutin. Differences in the degree of pigmentation between areas treated with 0.5% melanoston and application of vehicle only, and between before and after UVB exposure were considered to be significant (p<0.001, on each time).CONCLUSION:
We conclude that melanoston has an inhibitory effect on melanogenesis and some eliminating effect on preexisting pigmentation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arbutin
/
Skin
/
Volunteers
/
Yeasts
/
Pigmentation
/
Guinea
/
Monophenol Monooxygenase
/
Epidermis
/
Forearm
/
Guinea Pigs
Limits:
Animals
/
Female
/
Humans
Country/Region as subject:
Africa
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2006
Type:
Article
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