Contact Urticaria: Etiology and Blocking Effect of Some Drugs / 대한피부과학회지

ABSTRACT

This study was undertaken to investigate the response of nonimmunologic contact urticaria(NICU) test before and after ingestion of cimetidine, homoclorcyclizine and indomethacin. Thirty-five patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum (pet) by 20 minutes closed patch test were chosen and divided into 4 groups. Group I was consisted of 10 patients who were taken cimetidine 200 mg single dose, group 2, 9 patients, taken hornoclorcyclizine 10mg single dose or 30mg divided dose, group 3. 8 patients, taken indomethacin 100 mg single dose and group 4. 8 patients, taken indomethacin 50 mg tid. All the patients were tested with 5%. 2.5%. l%, 0.5%, and 0. l% BA in pet using Leukotape on the riight arm before rnedication and next day on the left arm after medication of each drug. Cimetidine and homoclorcyclizine did not show any significant differences before and after ingestion of drugs. Indomethacin, the cyclo-oxygenase inhibitor, blocked the reaction completely in half of the patients and reduced the reaction in almost all patients, regardless of doses. This results suggested that NICU induced by BA is not mediated by histamine but probably by prostaglandins.