Rapid Resolution of Atypical Hemolytic Uremic Syndrome by Eculizumab Treatment
Childhood Kidney Diseases
;
: 138-142, 2020.
Article
in English
| WPRIM
| ID: wpr-831205
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is an extremely rare and life-threatening disorder. Typical HUS is often caused by Shiga toxin-positive Escherichia coli, while aHUS is caused by dysregulation of the alternative pathway of the complement system in association with genetic abnormalities or development of autoantibodies. Eculizumab, a humanized anti-complement 5 monoclonal antibody, is recommended for the treatment of aHUS, but its long-term safety and efficacy in pediatric patients remain under review. In this paper, we report a pediatric case of aHUS with anti-complement factor H autoantibodies, who was treated successfully with eculizumab.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2020
Type:
Article
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