Clinical and Serological Findings in Patients with Toxocariasis in the Pohang Region: The Features of Toxocariasis in Pohang / 대한내과학회지
Korean Journal of Medicine
;
: 203-210, 2013.
Article
in Korean
| WPRIM
| ID: wpr-83140
ABSTRACT
BACKGROUND/AIMS:
This study was performed to investigate the clinical and serological characteristics of toxocariasis in the Pohang region.METHODS:
A total of 145 patients with peripheral eosinophilia (> 450 cells/microL) were enrolled and divided into two groups based on Toxocara excretory-secretory IgG enzyme-linked immunosorbent assay (ELISA) positivity, and the clinical features and serologic markers were compared between the two groups.RESULTS:
The seropositive rate of Toxocara was 62.1%. The serum total eosinophils (p = 0.038), total IgE level (p < 0.01), Dermatophagoides farinae (Df) seropositivity rate (p < 0.01), frequency of eosinophilic tissue infiltration in the lung or liver (p < 0.01), and ingestion of raw cow meat or liver (p < 0.01) were higher in seropositive patients than in seronegative patients. However, the presence of asthma and rhinitis (p < 0.01) were more frequent in seronegative patients. Among seropositive patients, positive correlations were observed between serum total IgE, total eosinophils, and the optical density value of the Toxocara IgG ELISA (p < 0.01; p = 0.015, respectively). The specific IgE to Df was significantly higher (p < 0.01) than that to Dermatophagoides pteronyssinus (Dp), suggesting a cross reaction between the Df antigen and the Toxocara antigen.CONCLUSIONS:
Patients who have elevated serum total IgE and have eosinophilia without allergic disease might have toxocariasis. The lower frequency of asthma or rhinitis and a tendency for higher specific IgE to Df than that to Dp could be useful findings for the diagnosis of toxocariasis in patients with eosinophilia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Toxocara
/
Immunoglobulin E
/
Immunoglobulin G
/
Enzyme-Linked Immunosorbent Assay
/
Toxocariasis
/
Rhinitis
/
Toxocara canis
/
Cross Reactions
/
Pyroglyphidae
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2013
Type:
Article
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