Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
Journal of the Korean Pediatric Society
;
: 451-455, 1998.
Article
in Korean
| WPRIM
| ID: wpr-83234
ABSTRACT
PURPOSE:
The universal vaccination against hepatitis B during early infancy is the only effective way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio at 2, 4, 6 months of age in babies of HBs antigen negative mothers.METHODS:
One hundred and eighty-one infants who were admitted to the Neonatal Intensive Care Unit (NICU), Chonnam University Hospital from August, 1994 to December, 1995 were enrolled in this study. Infants received Hepavax-B 0.5ml (10 microgram) at contralateral thigh intramuscularly, simultaneously with DPT vaccination. Antibody was assessed by MEIA (microparticle enzyme immunoassay) at seven to nine months of age.RESULTS:
The seroconversion rate of Hepatitis B after vaccination was 98.3%. There were no significant differences in positive rate of antibody according to gestational age, birth weight and sex. Seroconversion rate to hepatitis B in twins was lower than in singlets. Twenty-two infants among 23 infants, who were able to assess antibody titer, showed effective antibody titer, above 100mIU/ml.CONCLUSION:
The results suggest that the simultaneous administration of hepatitis B vaccine with DPT/TOPV is very effective and simplifies schedule. Moreover, this schedule will improve the compliance of vaccination.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appointments and Schedules
/
Poliomyelitis
/
Thigh
/
Twins
/
Birth Weight
/
Intensive Care, Neonatal
/
Gestational Age
/
Vaccination
/
Hepatitis B Vaccines
/
Compliance
Limits:
Humans
/
Infant
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1998
Type:
Article
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