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Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in MiddleAged Korean Adults
Diabetes & Metabolism Journal ; : 446-457, 2020.
Article | WPRIM | ID: wpr-832361
ABSTRACT
Background@#We examined the associations between thigh muscle area (TMA) and insulin resistance (IR) according to body mass index (BMI) in middle-aged Korean general population. @*Methods@#TMA was measured using quantitative computed tomography and corrected by body weight (TMA/Wt) in 1,263 men, 788 premenopausal women, and 1,476 postmenopausal women all aged 30 to 64 years. The tertiles of TMA/Wt were calculated separately for men and for premenopausal and postmenopausal women. Homeostatic model assessment for insulin resistance (HOMA-IR) was performed using fasting blood glucose and insulin levels, and increased IR was defined according to sex-specific, top quartiles of HOMA-IR. Associations between the TMA/Wt tertiles and increased IR according to the BMI categories (<25 and ≥25 kg/m2 ) were assessed using multivariable logistic regression analysis. @*Results@#In men with higher BMIs, but not in those with lower BMIs, the presence of an increased IR had significantly higher odds ratios in the lower TMA/Wt tertiles, even after adjustment for visceral fat area. However, in premenopausal and postmenopausal women, there was no significant inverse association between TMA/Wt tertiles and increased IR, regardless of BMI category. @*Conclusion@#Our findings suggest that the thigh muscle is inversely associated with IR in men, particularly in those with higher BMIs.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Journal: Diabetes & Metabolism Journal Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Journal: Diabetes & Metabolism Journal Year: 2020 Type: Article