Effect of cholestyramine on the formation of pigment gallstone in high carbohydrate diet-fed hamsters
Journal of Korean Medical Science
;
: 397-401, 1996.
Article
in English
| WPRIM
| ID: wpr-83327
ABSTRACT
This study was designed to investigate the effect of cholestyramine on the formation of pigment gallstones in high carbohydrate diet-fed hamsters and whether that effect occurred because of cholecystokinin action. Forty seven hamsters were divided into three groups group I(n = 16) was fed on normal rodent chow(43% carbohydrate), group II(n = 14) was fed on a high CHO diet(65% carbohydrate), group III(n = 17) was fed on a high CHO diet containing 4% cholestyramine. Gallstones developed in 0% of group I, 42.9% of group II and 5.9% of group III(P 0.05). In gallbladder bile analysis, there was also no significant difference between group II and group III in cholesterol, phospholipid, total calcium, total bilirubin and bile acid levels. In conclusion, cholestyramine decreases the frequency of pigment gallstone formation in high CHO diet-fed hamsters, but it is not clear whether the mechanism of cholestyramine decreasing the gallstone formation is due to the action of cholecystokinin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Pancreas
/
Phospholipids
/
Bilirubin
/
Pigmentation
/
Cholecystokinin
/
Dietary Carbohydrates
/
Cholelithiasis
/
Cholesterol
/
Cholestyramine Resin
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1996
Type:
Article
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