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Molecular epidemiology of Aleutian mink disease virus causing outbreaks in mink farms from Southwestern Europe: a retrospective study from 2012 to 2019
Journal of Veterinary Science ; : e65-2020.
Article | WPRIM | ID: wpr-833687
ABSTRACT
Background@#Aleutian mink disease virus (AMDV) causes major economic losses in fur-bearing animal production. The control of most AMDV outbreaks is complex due to the difficulties of establishing the source of infection based only on the available on-farm epidemiological data. In this sense, phylogenetic analysis of the strains present in a farm may help elucidate the origin of the infection and improve the control and biosecurity measures. @*Objectives@#This study had the following

aims:

characterize the AMDV strains from most outbreaks produced at Spanish farms between 2012–2019 at the molecular level, and assess the utility of the combined use of molecular and epidemiological data to track the possible routes of infection. @*Methods@#Thirty-seven strains from 17 farms were partially sequenced for the NS1 and VP2 genes and analyzed phylogenetically with other strains described worldwide. @*Results@#Spanish AMDV strains are clustered in four major clades that generally show a good geographical correlation, confirming that most had been established in Spain a long time ago. The combined study of phylogenetic results and epidemiological information of each farm suggests that most of the AMDV outbreaks since 2012 had been produced by within-farm reservoirs, while a few of them may have been due to the introduction of the virus through international trade. @*Conclusions@#The combination of phylogenetic inference, together with epidemiological data, helps assess the possible origin of AMDV infections in mink farms and improving the control and prevention of this disease.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Screening study Journal: Journal of Veterinary Science Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Observational study / Screening study Journal: Journal of Veterinary Science Year: 2020 Type: Article