Calcitonin Gene-related Peptide Immunoreactivity in the Muscle Layer of Small Intestine; Its Action on Interstitial Cell / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 207-214, 2004.
Article
in Korean
| WPRIM
| ID: wpr-83425
ABSTRACT
In addition to the central and the peripheral nervous system, calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) has been identified throughout the enteric nervous system. Several functions of the CGRP in gastrointestinal (G-I) tract has been identified, but the effect of CGRP on G-I motility is unclear. The distribution of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in the murine small bowel were studied by using immunohistochemistry, also analyzed functionally by using electrophysiological method. Immunohistochemical studies demonstrated that CGRP-LI is localized in both nerve fibers and myenteric ganglion cells in the whole-mount preparation of murine small intestine. Double labelling with CGRP and c-kit investigated by confocal microscope was shown that CGRP-LI enteric nerve fiber surrounded the c-kit positive interstitial cells of Cajal (ICC). Electrophysiological finding revealed that treatment of CGRP inhibited electrical activity on culture ICC. Our results suggest a CGRP innervation of murine small bowel ICC. The released CGRP from enteric nerve terminals may induce relaxation of small bowel through the inhibition of ICC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Relaxation
/
Calcitonin
/
Immunohistochemistry
/
Calcitonin Gene-Related Peptide
/
Peripheral Nervous System
/
Enteric Nervous System
/
Ganglion Cysts
/
Interstitial Cells of Cajal
/
Intestine, Small
/
Nerve Fibers
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Physical Anthropology
Year:
2004
Type:
Article
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