Effects of ozone on influenza virus-induced airway hyperreactivity in rats / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 749-754, 2000.
Article
in Korean
| WPRIM
| ID: wpr-83473
ABSTRACT
BACKGROUND:
Ozone is one of the most ubiquitous oxidant in urban air and may exacerbate respiratory diseases such as asthma.OBJECTIVE:
We examined whether ozone can influence airway hyperresponsiveness induced by influenza virus-infection. SUBJECT ANDMETHOD:
Rats were exposed to ozone, acutely to 1.0ppm and 0.25ppm for 23.5hrs. At 2hrs post cessation of ozone exposure, animals were infected with rat-adapted influenza virus intra-nasally. On day 3 post-virus inoculation, pulmonary mechanics were measured during an intravenous challenge with acetylcholine . Cumulative doseresponse functions were obtained by doubling the rate of the intravenous infusion every 2min.RESULTS:
ACh increased airway resistance in a dose-dependent manner. Neither of the concentrations of ozone altered the airway responses to ACh. Animals infected with virus developed hyperresponsiveness to ACh as was expected. Pre-exposure to 1.0ppm ozone for 23.5hrs aug- mented the virus-induced airway hyperresponsiveness, while 0.25ppm did not.CONCLUSION:
Acute exposure to ozone can synergistically act on virus-induced airway hyperreactivity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthomyxoviridae
/
Ozone
/
Asthma
/
Infusions, Intravenous
/
Acetylcholine
/
Airway Resistance
/
Mechanics
/
Influenza, Human
Limits:
Animals
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
2000
Type:
Article
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