Detailed Analysis of Chromosome Aberrations in Human Leukocyte Induced by Anti-malignant Tumor Agent (FT-207)
Yonsei Medical Journal
;
: 7-15, 1978.
Article
in English
| WPRIM
| ID: wpr-8351
ABSTRACT
The anticancer agent's FT-207, N1-(2'-tetrahydrofuryl)-5-fluorouracil, a derivative of 5FU (5-fluorouracil), induced chromosome damage to the human leukocyte was investigated. FT-207 inhibit mitosis and cause chromatid and chromosome breakage and chromatid exchange with 20 ug/ml for 48 to 72 hours of treatment. However, with 15 ug/ml for 72 hours only delayed spiralization was produced in some of the chromosomes in the same cells. The random distribution of chromosome breakage were observed and the effect of FT-207 on the chromosomes of human leukocytes were time dependent rather than concentration dependent. The comparision of the effect of mitomycin C on human leukocytes and the action of FT-207 at specific times during the cell cycle were discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Cells, Cultured
/
Chromosome Aberrations
/
Tegafur
/
Fluorouracil
/
Leukocytes
/
Mitotic Index
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1978
Type:
Article
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