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The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
Immune Network ; : e20-2020.
Article | WPRIM | ID: wpr-835464
Responsible library: WPRO
ABSTRACT
Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
Full text: Available Index: WPRIM (Western Pacific) Journal: Immune Network Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Journal: Immune Network Year: 2020 Type: Article