Studies of Brain Edema in Experimental Intracerebral Hematoma

ABSTRACT

An experiment was designed to investigate the brain edema with temporary microballoon to simulate intracerebral hemorrhage. A temporary mass lesion was made on the region of right basal ganglia(0.4 ml) with inflatable microballoon. After a 5 hours inflation state, the balloon was deflated and then we measured water content of the brain by vacuum freeze drying method at regular interval according to the groups. And we compared it with sham-treated group(balloon insertion without inflation) and permanent group(balloon inflation without deflation) respectively. There was no significant difference in water content between both hemispheres of all groups. In temporary group, the water contents of both hemisphere were higher than control group for initial 7 days, but became normalized in 4 weeks. The water content of cortex was higher than that of white matter for initial 7 days but reversed in 4 weeks comparatively in temporary group.