Augmented immune responses in pigs immunized with an inactivated porcine reproductive and respiratory syndrome virus containing the deglycosylated glycoprotein 5 under field conditions
Clinical and Experimental Vaccine Research
;
: 70-74, 2016.
Article
in English
| WPRIM
| ID: wpr-8371
ABSTRACT
PURPOSE:
Porcine reproductive and respiratory syndrome virus (PRRSV) leads to major economic losses in the swine industry. Vaccination is the most effective method to control the disease by PRRSV. MATERIALS ANDMETHODS:
In this study, the efficacy of a glycoprotein (GP) 5-modified inactivated vaccine was investigated in pigs. The study was performed in three farms farm A, which was porcine reproductive and respiratory syndrome (PRRS)-negative, farm B (PRRS-active), which showed clinical signs of PRRS but had not used vaccines, and farm C (PRRS-stable), which had a history of endemic PRRS over the past years, but showed no more clinical signs after periodic administration of modified live virus vaccine.RESULTS:
The inactivated vaccine induced great enhancement in serum neutralizing antibody titer, which was sufficient to protect pigs from further infections of PRRSV in a farm where pre-existing virus was circulating.CONCLUSION:
These results indicated that vaccination with the inactivated vaccine composed of viruses possessing deglycosylated GP5 would provide enhanced protection to pigs from farms suffering from endemic PRRSV.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Neutralization Tests
/
Vaccines
/
Glycoproteins
/
Vaccines, Inactivated
/
Vaccination
/
Porcine respiratory and reproductive syndrome virus
/
Porcine Reproductive and Respiratory Syndrome
/
Antibodies, Neutralizing
Language:
English
Journal:
Clinical and Experimental Vaccine Research
Year:
2016
Type:
Article
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