Effects of Exercise Training on Vascular Endothelial Function Related Factors of Obese Elderly Women with Sarcopenia / 대한스포츠의학회지

ABSTRACT

Purpose@#This study examined how 12-week regular exercise training affects changes in body composition and factors related to vascular endothelial function including blood nitric oxide (NO) in elderly women with sarcopenic obesity. @*Methods@#Subjects were divided into exercise group (n=15) and control group (n=15) for sarcopenic obese elderly women with 30% or more of body fat and less than 7.67 kg/m2 of appendicular skeletal muscle mass (ASM)/height2 .Before and after 12 week exercise training, body composition, blood pressure, intima-media thickness of carotid artery, blood lipid profiles, NO, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), malondialdehyde, cortisol concentrations were measured and compared. @*Results@#In the exercise group, after exercise training, body weight and body fat percentage decreased significantly (p＜ 0.05) and ASM/height2 increased significantly (p＜ 0.05). Systolic blood pressure, intima-media thickness of left carotid artery and blood lipid levels decreased significantly (p＜ 0.05), and blood NO and eNOS increased significantly (p＜ 0.05). However, the control group was not significantly different between before and after exercise training. The amount of change in ASM/height2 after exercise training showed a significant (p＜ 0.05) correlation with the change in blood NO concentration and intima-media thickness of left carotid artery. @*Conclusion@#Regular exercise training for 12 weeks helps to relieve sarcopenic obesity in the elderly, and positive changes in body composition with increased muscle mass can be drive to positive changes in factors related to vascular endothelial function with blood NO, eNOS and lipids. These effects of exercise training thought to help the improvement of blood pressure and intima-media thickness of carotid artery.