Analysis of screening results of 50492 newborns with G6PD deficiency in Huangshi area / 公共卫生与预防医学

ABSTRACT

Objective To analyze the incidence of neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency in Huangshi area, and to provide guidance for neonatal disease screening. Methods Fluorescence immunoassay was used to detect G6PD activity in an initial screening. Children who were positive in the first screening were recalled for a second screening. Second screening positive children were recalled for G6PD gene testing. Results A total of 105 newborns were positive in the first screening, for a positive rate of 0.21%. A total of 93 cases were recalled, and the recall rate was 88.60%. There were 77 cases positive in the second screening, and the positive rate was 82.80%. A total of 65 patients were recalled, of which 49 neonates were diagnosed, 1 was normal, and 15 refused gene testing. The incidence rate was 0.10%. Conclusion The incidence of newborn G6PD deficiency in Huangshi area is relatively low, which is consistent with the disease distribution trend of “south high-north low”.