Anxiety, depression and related factors in lung cancer inpatients / 第二军医大学学报

ABSTRACT

Objective To investigate the status of anxiety and depression in lung cancer inpatients and to explore their influencing factors. Methods One hundred lung cancer patients, who were treated in Changhai Hospital of Naval Medical University (Second Military Medical University) from Nov. 2016 to May 2017, were enrolled in this study. The demographic, sociological and clinical characteristics of the inpatients were collected by self-designed questionnaires through cross-sectional survey. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were employed to evaluate the anxiety and depression symptoms of the lung cancer inpatients, respectively. Pearson correlation analysis, Fisher exact test, Χ2 test and multiple linear regression analysis were used to analyze the correlation of anxiety and depression and the related factors. Results The incidence rates of depression and anxiety in lung cancer inpatients was 20.0% (20/100) and 48.0% (48/100), respectively. The SAS and SDS scores of lung cancer inpatients were significantly higher than the normal values (both P<0.01). SAS score was positively correlated with SDS score (r=0.409, P<0.001). The rate of comorbidity of depresson and anxiety was high. The proportion of anxiety inpatients with comorbid depression was 85.0% (17/20). The proportion of depressive inpatients with comorbid anxiety was 35.4% (17/48). Univariate analysis showed that child number and tumor metastasis were significantly correlated with anxiety symptoms in the lung cancer inpatients. The inpatients having 0-1 child had significantly higher incidence of anxiety versus those having 2 or more children (P=0.042). The inpatients with tumor metastasis had significantly higher incidence of anxiety versus those without metastasis (P=0.044). Multiple linear regression analysis showed that child number and clinical stage of tumor were the influencing factors of anxiety in the lung cancer inpatients, with the standard regression coefficients being -0.238 and 0.202, respectively (both P<0.05). Conclusion The incidence rates of anxiety and depression are high in lung cancer inpatients, and there is a strong correlation between depression and anxiety. Number of child, clinical stage of tumor and tumor metastasis can influence the severity of anxiety. Clinicians should pay attention to the psychological status of lung cancer patients, identify depression and anxiety symptoms in time, and carry out individualized psychological therapy and drug therapy according to the characteristics of patients.