Relationship between platelet parameters and delayed graft function after renal transplantation / 第二军医大学学报

ABSTRACT

[Abstract] Objective To explore the relationship between the changes of platelet parameters after renal transplantation and delayed graft function (DGF). Methods A retrospective analysis was conducted with 109 patients who underwent allograft renal transplantation from Jul. 2016 to May 2018 in the Department of Organ Transplantation of Changhai Hospital, Naval Medical University (Second Military Medical University). The patients were divided into DGF group (n＝41) and non-DGF group (n＝68). Peripheral blood samples were collected from the two groups before and at 1, 3, 7 and 14 d after operation. The platelet parameters, including platelet count (PLT), platelet-large cell ratio (P-LCR), mean platelet volume (MPV), platelet volume distribution width (PDW) and platelet hematocrit (PCT), were dynamically monitored. Receiver operating characteristic (ROC) curve was used to analyze the value of the platelet parameters for predicting DGF after renal transplantation. Results There was no significant difference in platelet parameters between the DGF group and the non-DGF group before operation. At 1, 3, 7, and 14 d after renal transplantation, PLT values in the DGF group were lower than those in the non-DGF group, MPV values were higher than those in the non-DGF group, with statistical significance found at 7 d after renal transplantation (both P0.05). PCT in the DGF group was decreased first and then increased after renal transplantation. At 7 d after operation, PCT in the DGF group was markedly lower than that in the non-DGF group (P0.05). PDW and P-LCR in the DGF group and the non-DGF group increased first and then decreased after renal transplantation. At 7 d after operation, PDW in the DGF group was markedly higher than that in the non-DGF group (P0.05). There was no significant difference in P-LCR between the two groups at 7 d after operation (P＝0.184). At 7 d after operation, the area under ROC curve for PDW and PCT were 0.781 and 0.758, with the optimal cut-off values being 16.75 fL and 0.155%, specificity being 92.6% and 63.2%, and sensitivity being 61.0% and 75.6%, respectively. Conclusion Dynamic monitoring of platelet parameters early after renal transplantation is helpful for the early diagnosis of DGF. There is an increased risk of DGF in patients with PDW16.75 fL and PCT0.155% at 7 d after operation.