Role of hypoxia, glucose metabolism and fat metabolism in pathogenesis of rheumatoid arthritis: An update / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 297-301, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-838269
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial membrane inflammation. The pathogenesis of RA is unknown, and the related researches mainly focus on inflammation and immune response. Recent researches have found that metabolism is closely related to immunity. Besides, hypoxia and metabolic disorders of glucose and fat can also affect the development, differentiation and function of immune cells, and then lead to occurrence of autoimmune diseases. In recent years, more and more studies have focused on the role of metabolic pathways in the immunity and pathogenesis of RA, in order to explore the pathogenesis of RA from different perspectives and to provide new ideas for the treatment of RA. In this review, we summarized the role of hypoxia, glucose metabolism and fat metabolism in immunity and pathogenesis of RA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2018
Type:
Article
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