Precision medicine and prostate cancer / 第二军医大学学报

ABSTRACT

IN post-human genomic era, the concept of precision medicine has provided opportunities for “reinterpretation” and “new orientation” for cancer therapy including prostate cancer. Prostate cancer is the leading cause of cancer-related death in men, and its traditional treatment meets bottleneck and needs broken through, while the concept of precision medicine is starting to have positive effect. Precision medicine has potential values in optimizing the clinical reclassification of patients, androgen deprivation therapy (ADT), chemotherapy, and radiation therapy strategies for prostate cancer. When traditional treatment of prostate cancer gradually loses efficacy, the prostate cancer molecular subtyping map and the development of targeted therapies are expected to bring new breakthrough. At the same time, precision medicine also prompts new therapeutic concepts for prostate cancer, such as reconstruction of the immune environment, tumor-specific neoantigens prediction, and organoid culture system. The future of precision medicine has been widely embraced and it will have promising application in the diagnosis and treatment of prostate cancer. However, currently the benefit of precision treatment of cancer is still far below the public expectations. Like for many emerging concepts, the potentially huge market behind precision medicine inevitably breeds overheated commercial propaganda. Full communication and cooperation of scientific researchers with clinical doctors and patients, and standardization and guidance of health administration are the keys to ensure that precision medicine benefits for human health.