DNA methyldtion and asthma: Recent progress / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 220-225, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-838373
ABSTRACT
DNA methylation is one of the most common forms of epigenetic modification, and t is closely related to the development of bronchial asthma, but its mechanism is unclear. Without altering the sequences of genes, DNA methylation can transfer the cytosine on the 5 end of CpG dinucleotide into methyl cytosine by DNA methyltransferase. Hence, DNA methylation can regulate gene expression, leading to the development and progression of diseases. In this review, we summarized the roles of DNA methylation in bronchial asthma, including related predisposing factors and mechanisms of action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2017
Type:
Article
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