Proposing “nano-based physical pharmacy” principle for overcoming bottlenecks in development of nanomedicine / 第二军医大学学报

ABSTRACT

Nanomedicine has shown huge potential in the treatment of cancer, which is not only due to the fact that it can overcome the drawbacks of some small molecular drugs such as insolubility, rapid metabolism, and bad targeting, but also realize the multi modality treatment by containing A minor of nanomedicine can be approved for clinical applications due to poor stability and rapid metabolism, resulting in the limited efficacy and bottlenecking the development of Nanomedicine, that is, “excellent performance in vitro -poor performance in vivo ”. We believe that the fundamental solution in nanomedicine depends on its basic physical and chemical properties, that is the research and innovation of physical pharmacy theoretical methods of nanopreparation. Herein, Focusing on the statistics of tumor microenvironment and targeting the practical clinical The rats were treated with aerobic chemotherapeutic drugs as an example, we systemically elaborated The relationship of the physicochemical properties including the carrier composition, self-assembly, drug loading and release, and stability with in vitro and in vivo properties, and explored the related mechanism in vivo.