Role of vascular endothelial growth factor-a in kidney development and kidney diseases / 第二军医大学学报

ABSTRACT

The renal vascular system is vital for maintaining the normal function of kidney, and vascular endothelial growth factor-A (vEGF-A) participates in the development of renal vascular.system and is associated withvarious kidney diseases. Studies have demonstrated that down-expression of renal vEGF-A can result in reduction of microvascular density in medulla kidney, regional hypoxia, and polycythemia, and further lead to increased haemopoietin. The overexpression of vEGF- A can cause renal fibrosis and cyst formation, promoting the progress of kidney disease. Therefore, regulation of vEGF-A expression may influence the occurrence and development of kidney diseases. This review summarized the role of vEGF-A in the renal vascular system and kidney diseases hoping to provide new therapeutic strategies for kidney diseases.