Effect of Alpha-Chymotrypsin on the Outflow Facility in Rabbit Eyes
Journal of the Korean Ophthalmological Society
;
: 1-6, 1968.
Article
in Korean
| WPRIM
| ID: wpr-83871
ABSTRACT
Alpha-chymotrypsin solutions, 200 unit/ml and 1,000 unit/ml, were injected into the anterior chamber of albino rabbit eyes fonowed by irrigation with normal saline after 3 minutes. Intraocular pressure was recorded by pressure transducer and pressure decay curve analysis was made to calculate the outflow facility according to the method of Eisenlohr and Langham. The follow-up periods were 30 days after the injection of the enzyme solution. By the injection of 0.25 ml of 200 unit/ml solution in 7 eyes, intraocular pressure showed almost no changes throughout the observation period. Outflow facility showed transient decrease during the first 3 to 5 days in some eyes. After the injection of 0.25 ml of 1,000 unit/ml solution in 3 eyes, transient elevation of the intraocular pressure was noted associated with decrease in outflow facility. In one eye, a marked rise in ocular pressure was found All the changes in intraocular pressure and outflow facility returned to the pre-treatment level within 30 days. It was concluded that high concentration of the alpha-chymotrypsin solution injected into the anterior chamber might cause disturbances in trabecular function causing elevation in intraocular pressure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transducers, Pressure
/
Follow-Up Studies
/
Intraocular Pressure
/
Anterior Chamber
Type of study:
Observational study
/
Prognostic study
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1968
Type:
Article
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