A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
Natural Product Sciences
;
: 213-216, 2017.
Article
in English
| WPRIM
| ID: wpr-83903
ABSTRACT
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants
/
Acetylcholinesterase
/
Cholinesterase Inhibitors
/
Coumarins
/
Heracleum
/
Methods
Language:
English
Journal:
Natural Product Sciences
Year:
2017
Type:
Article
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