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A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
Natural Product Sciences ; : 213-216, 2017.
Article in English | WPRIM | ID: wpr-83903
ABSTRACT
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants / Acetylcholinesterase / Cholinesterase Inhibitors / Coumarins / Heracleum / Methods Language: English Journal: Natural Product Sciences Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants / Acetylcholinesterase / Cholinesterase Inhibitors / Coumarins / Heracleum / Methods Language: English Journal: Natural Product Sciences Year: 2017 Type: Article