ABO blood group and the risk of gastric cancer: A case-control study and meta-analysis / 第二军医大学学报

ABSTRACT

Objective: To evaluate the relationship between ABO blood group system and the risk of gastric cancer by case-control study and meta-analysis. Methods: In our case-control study, 930 cases of gastric cancer were enrolled and 8 426 cases with other diseases were taken as controls from Changhai Hospital. PubMed were searched with unlimited initial time and the cutoff time on December 31, 2013; and our case-control study was also included. Two reviewers evaluated the quality of the included case-control studies by Newcastle-Ottawa scale (NOS) and extracted the data independently. The meta-analysis was performed by Meta-Analyst 3. 13 software. Results: The case-control study showed that blood type A might be a risk factor of gastric cancer (0R=1. 58;95%CI 1. 37-1. 81). The results of meta-analysis showed that the risk of gastric cancer of blood group A was signiticantly higher than that of non-A groups (0R=1. 28; 95%CI 1. 01-1. 62); meanwhile, blood group O demonstrated a lower risk of gastric cancer compared with non-O groups (OR=0. 84;95%CI 0. 73-0. 96); subgroup analysis found differences between home population and foreign population. Conclusion: ABO blood group system is associated with the risk of gastric cancer, and type A might be one of the risk factors of gastric cancer.