Pharmacokinetics evaluation of curcumin-phospholipid complex / 第二军医大学学报

ABSTRACT

Objective: To evaluate the pharmacokinetics of curcumin phospholipid complex (CCPC) in rats following oral administration. Methods: Blood samples were collected from the retinal venous plexus of SD rats after oral administration of CCPC or curcumin (CC), and the blood concentration of curcumin was determined by high-performance liquid chromatography (HPLC). Results: The solubility and cumulative dissolution of CCPC (0.150 g/L and 68.04%, respectively) were higher than those of CC (0.057 g/L and 50.68%, respectively). The pharmacokinetic parameter of CCPC and CC were calculated as follows Cmax (74.34±5.57) μg/L and (61.64±4.29) μg/L, Tmax (0.17±0) h and (0.25±0) h, AUC0-t (637.38±30.04) μg·h·L-1 and (172.41±31.66) μg·h·L-1, and AUC0-∞ (857.80±223.69) μg·h·L-1 and (191.08±43.27) μg·h·L-1, respectively. The intra-day, inter-day precision, and recovery rate met the criteria for content determination. Conclusion: Compared with curcumin, CCPC can be absorbed more rapidly and eliminated more slowly.