Long noncoding RNAs and lung cancer / 第二军医大学学报

ABSTRACT

Long noncoding RNAs (lncRNAs), contraining more than 200 nucleotides, are RNA transcripts without protein-coding capacity. It has been reported that lncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels, and are deeply involved in various biological processes. Many diseases are found related to lncRNAs and they have become a focus of studies. According to recent evidences, a number of lncRNAs are changed in lung cancer, and they play a significant part in the development, progression and prognosis of lung cancer. This review focuses on the definition and functional mechanism of lncRNAs and their relation with lung cancer.