LDL cholesterol/HDL cholesterol ratio in newly diagnosed type 2 diabetic patients complicated with metabolic syndrome / 第二军医大学学报

ABSTRACT

Objective To investigate the change of low-density lipoprotein cholesterol (LDL-C) /high-density lipoprotein cholesterol (HDL-C) ratio in newly diagnosed patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), and to discuss its relationship with the clinical parameters. Methods Totally 140 newly diagnosed T2DM patients were selected for this study, and they were divided into MS group (n=73) and non-MS group (n=67) according to the presence of MS; the normal control group included 73 participants (NC group). All participants underwent an oral glucose tolerance test (OGTT) and insulin releasing test; meanwhile, the blood glucose, insulin, blood lipid and other items were measured. The LDL-C/ HDL-C ratios of each group were calculated. Clinical parameters and LDL-C/HDL-C ratios were compared among different groups, and correlation analysis was made between LDL-C/HDL-C ratios and clinical indices. Furthermore, all participants were divided into three groups according to LDL-C/HDL-C levels and the prevalence rates of MS were compared. Results The LDL-C/HDL-C ratios of MS group (3.18±0. 85) and non-MS group (2. 61±0. 93) were significantly higher than that in NC group (2. 26 ±0. 70, Pprevalence rates of MS were significantly increased in the patients with the elevation of LDL-C/HDL-C (11. 27%, 35.21%, and 56.34%, Panalysis showed that LDL-C/HDL-C ratio was positively correlated with the body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), postprandial plasma glucose (PPG), fasting insulin (FINS), postprandial insulin (PSI), homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride (TG), cholesterol (CHOL) and LDL-C CPregression analysis showed that HDL-C, LDL-C and FINS entered the equation CPpatients complicated with MS, and the prevalence rate of MS is higher in patients with high LDL-C/HDL-C value. The ratio of LDL-C/HDL-C may be a better index for the early detection of MS compared with LDL-C, which provides a simple, feasible strategy for the prevention and treatment of MS.