Melioidosin is a main virulent factor of Bulkholderia pseudomallei / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 1281-1286, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-839302
ABSTRACT
Objective To investigate the pathogenic role of melioidosin in pathogenicity of Burkholderia pseudomallei (B. pseudomallei). Methods A synthetase gene associated with melioidosin synthesis in B. pseudomallei was inactivated by homologous recombination. Melioidosin producting ability and the virulent effects of the wild-type and mutant B. pseudomallei upon microorganisms (Penicillium spp., Aspergillus niger spp., Streptococcus faecalis spp. and Staphyloccocus arreus spp.), C. elegans and BALB/c mice were compared. Results The mutant B. pseudomallei underwent notable morphology change, lost the ability to form bacterial membrane and the virulent effects to microorganisms, C. elegans and BALB/c mice. Conclusion It suggests that melioidosin is one of the main virulent factors of B. pseudomallei.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS