Correlation of high-resolution CT volumetric data with body mass index in patients with chronic obstructive pulmonary disease / 第二军医大学学报

ABSTRACT

Objective To explore the association of body mass index (BMI) with high-resolution CT (HRCT) volumetric data and HRCT phenotypes in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty-two consecutive C0PD patients underwent HRCT and their weight and height were recorded. C0PD subjects were classified into three phenotypes based on the visual HRCT findings (with or without emphysema and/or bronchial wall thickening). With the volumetric HRCT data, the total lung volume (TLV) was calculated automatically by Extended Brilliance WorkspaceTM, the total emphysema volume (TEV) was obtained by applying density thresholds of-950 HU, and the TEV/TLV was calculated as an emphysema index (EI). The correlation between the volumetric HRCT data and BMI was assessed using Spearman correlation analysis. The three phenotypes of C0PD subjects were evaluated using one-way AN0VA. Results Visual HRCT findings showed that the C0PD patients were classified into 3 phenotypes phenotype A (n = 42), phenotype E (n = 9) and phenotype M (n = 11). BMI of C0PD patientswas correlated with both TEV (r= - 0. 389, P = 0. 002) and EI (r= -0. 424, P = 0. 001). C0PD patientswith phenotype A had a significantly higher BMI ([23. 4±3. 4] kg/m2) compared with those with phenotype E ([20. 6±3. 1] kg/m2, P<0. 05). The BMI of patients with phenotype M ([21. 3±2. 7] kg/m2) was not significantly different from those of phenotypes A or E. Conclusion The TEV and El are negatively correlated with BMI in COPD patients. HRCT phenotype A compared with phenotype B and C is associated with a higher BMI in COPD patients.