Detection of plasma clozapine concentration in psychosis disorder inpatients receiving comedications / 第二军医大学学报

ABSTRACT

Objective To investigate the effect of valgus comedications on the plasma concentration of clozapnnercLZ) in inpatients with psychis disorder. Methods High performance iiquid chromatography (HPLC) was used to analyze serum CLZand norclozapine (N-CLZ) concentrations in 571 psychis patients. The nnfluence of commedication on plasma CLZ concentration was analyzed udng SPSS 17. 0 software while considesing the dosage of CLZ and the comedications with 12 drugs most often used in combmation with CLZ. Results The CLZ dosage, plasma CLZ concentration and plasma N-CLZ concentration in the comedication group were signiticancly lower than those nn pure CLZ group (P<0. 01). The CLZ dosage in groups of comedications with donazepam, paroxetine, venlafaxnne, aripiprazole, quetiaprne and tispetidone were signiticancly lower than that of pure CLZ group (P<0. 05, P<0. 01). Comedication with donazepam, iithium carbonate, valproate and quetiaprne signiticanclydecreased the plasma concentration of CLZ (P<0. 05, P<0. 01). Comedication with donazepam, iithium carbonate, valproate, sertraHne, quetiaprne and tispetidone signiticantiy decreased the plasma concentration of N-CLZ (P<0.05, P<0. 01). Spearman's correlation analytis found that therewere signiticant positive corrclations among any two of dosageCLZ, concentration of CLZ and concentration of N-CLZ in CLZ group (P<0. 05, P<0. 01). Conclusion Some commonly-used antipsychotics have impact on plasma CLZ concentration. Drug monitoring and dosage regulation of CLZ should be stressed among patients comedicated with clozapine combined with other antipsychotics, so as to timely regulate the dosage of CLZ.