Analysis of clinical characteristics and risk factors in 85 newly diagnosed patients with type 2 diabetes mellitus / 第二军医大学学报

ABSTRACT

Objective To explore the clinical characteristics and risk factors of newly diagnosed type 2 diabetic mellitus (T2DM) patients and to investigate the correlations among nonalcoholic fatty liver disease (NAFLD), hyperuricemia, neck circumference (NC) and carotid intima-media thickness (CIMT) in these patients. Methods The 85 patients were all within one year after diagnosis and they were hospitalized immediately after diagnosis. The clinical data including NC, waiit circumference (WC), waitt-hip ratio (WHR), and body mass index (BMI) were collected. The fasting insulin, fasting C-peptide, hemoglobin A1c, liver and renal function, phenotype of lipid and uric microalbumin were determined, and ultrasound examination of the liver and carotid artery was performed. Results The prevalence rates of NAFLD, hyperuricemia and increased CIMT were 57.6% (49/85), 16. 5% (14/85) and 29. 4% (25/85), respectively. Up to 88. 2% (75/85) of the patients had two or more metabolic abnormalities. Patients withNAFLD, hyperuricemia and increased NC had significantly more metabolic abnormalities compared with those without the corresponding conditions (P<0. 05). The BMI, NC, WC, alanine aminotransferase (ALT), and triglyceride (TG) were significantly different among different groups (all P < 0. 05). Multivariate unconditional logistic regression analysis showed that NC, WC, BMI, ALT, fasting C-peptide, and serum uric acid (SUA) were common risk factors of NAFLD and increased CIMT. Conclusion Mott newly diagnosed T2DM are concomitant with a variety of metabolic abnormalities. NAFLD, hyperuricemia, increased NC and CIMT are risk factors to each other. NC and SUA are also the common risk factors of NAFLD and increased CIMT.