Effect of Danshen on pharmacokinetics of Rosuvastatin in rats / 第二军医大学学报

ABSTRACT

Objective To study the effect of Danshen on the pharmacokinetics of Rosuvastatin in rats. Methods Parallel control method was applied in this study. Twelve male rats weighing (230 ± 15) g were evenly randomized into two groups rosuvastatin (80 mg/kg) group and Rosuvastatin plus Danshen (400 mg/kg) group. Blood samples (0. 3 ml each) were collected from the orbital vein at 0. 5, 1, 1. 5, 3, 5, 8, 10, 12 and 24 h after drug administration. LC-MS was used to determine the plasma concentrations of Rosuvastatin. The pharmacokinetic parameters of the two groups were compared and statistical analysis was performed using SPSS12. 0 software. Results When combined with Danshen, the Cmax, AUC0-t, and AUCo-∞ of Rosuvastatin were increased by 60. 81%, 88. 00% and 82. 92%,and T1/2 and CLz/F were reduced by 33. 21% and 21. 51%, respectively. Conclusion Danshen can affect the pharmacokinetic properties of Rosuvastatin in rats.