Astrocyte elevated gene 1 as a multifunctional regulator in cancer progression / 第二军医大学学报

ABSTRACT

Astrocyte elevated gene 1 (AEG-l), an important oncogene, has been confirmed to play a crucial role in progression (invasion, metastasis, angiogenesis and chemoresistance, etc) of multiple cancers. Over the past decade, studies have shown that AEG-l is overexpressed in cancers involving almost all organs, including neuroblastoma, melanoma, HCC, breast, prostate cancer, etc. Moreover, AEG-l is associated with multiple pathways including PI3/Akt and nuclear factor-kappa;B; (NF-kappa;B;). This review mainly outlines the multiple regulating role of AEG-l in the development and progression of tumor and to discuss its role as a novel target for treatment of malignant tumors.