A family-based transmission disequilibrium test of single nucleotide polymorphisms in exon 4 of ZNF804A gene in Han Chinese patients with schizophrenia / 第二军医大学学报

ABSTRACT

Objective To investigate the association of the single nucleotide polymorphisms (SNPs) in exon 4 of ZNF804A gene with schizophrenia in a family-trios sample. Methods MassARRAY genotyping technique and the transmission disequilibrium test (TDT) were employed to study the association of SNPs (seven nonsynonymous and two intronic) encompassing exon 4 of ZNF804A gene with schizophrenia in 69 nuclear families. Results (1) Four SNPs (rs79776875, rs78816540, rs79082132 and rs62198467) in this study were found to be rare variants (0<minor alíele frequencyanalysis. (2) The TDT result of rs4667000, rs61739290, rs61739288, rsl366842 and rs3731834 showed that it was significant for marker rs3731834 (P<0. 05). (3) Linkage disequilibrium analysis showed significant association in five-SNP haplotype test (global P<0. 05). Conclusion The results suggest that SNPs in exon 4 of ZNF804A gene is associated with schizophrenia susceptibility in Han Chinese population.